Erectile Dysfunction: Viagra And Other Oral Medications

Erectile Dysfunction: Viagra And Other Oral Medications
  • Posted On: Aug 24, 2021
  • By: Admin

Millions of men with erectile dysfunction were lucky by the accidental invention of the ED drug Sildenafil in 1998. In the next two decades, its brand medicine Viagra skyrocketed in sales to earn billions for its patented company, Pfizer. After the patent expired, it became a generic medicine sold in many brand names at cheaper costs to help men with ED to have enough erection for having a satisfying sexual life. After Sildenafil, other oral medicines were similar or with minor variations to treat ED like Vardenafil, Tadalafil, Avanafil, and others.

Hence, continue reading about erectile dysfunction and its many oral medications and their differences in treating it for a happy life.

History Or Erectile Dysfunction Management

Erectile dysfunction issues for men are there from time unknown.

Though there were many ancient remedies only from the last few centuries, there was enough evidence of attempts to treat it. For example, in 1668, Regnier de Graaf discovered that saline injection into the corpses' penile blood vessels might induce erection. In addition, there were many methods tried from the early 1900s. It includes vacuum devices, penile implants, venous leakage, local therapies like intracavernosal and intraurethral agents. But it was only in 1998, the first scientifically proven oral medication, Sildenafil, transformed ED management among men worldwide.

Why Are Oral Medications The Best Help For Erectile Dysfunction?

Oral medications are a safe and straightforward way of treating erectile dysfunction with little or no side effects. Since scientifically proven with many clinical trials for the world's famous drug authorities approving these oral medications, they are the best help for erectile dysfunction. Furthermore, easy and fast online availability makes it the best option for having enough erection during sexual intercourse. However, though there are other methods like surgery, penile implants, and others, they are all expensive and impossible for older or chronically affected men. And when compared with the traditional vacuum pump and other therapies, they are not convenient as taking oral medication. Hence, only the oral medications best suit ED-affected men in costs, convenience, and safety.

Are All ED Oral Medications Have The Same Effect?

Erectile dysfunction is mild, moderate, or complete for men, and it increases with age. There are many physical and psychological causes for it to happen to men for not having enough erection to satisfy their partners. Depending on the severity and the cause of the erectile dysfunction, the effects of the ED oral medications differ. Despite all working as PDE5 or phosphodiesterase, five inhibitors stop the enzyme that reduces the erection potency. By blocking this PDE5 enzyme, there is a free flow of blood to the penis as soon as men experience sexual arousal. Therefore, it gives enough erection after taking these ED oral medications to have satisfying sexual intercourse. But with many ED oral medications now available, the following are how these ED oral medicines differ in giving erection, timing, side effects, and others.

Differences Between The Oral Medications For Treating ED

  • Sildenafil with doses ranging from 50 to 100 milligrams is still the first choice for men with ED for the past two years as they provide the most effective ED treatment but may have visual changes as the significant side effect.
  • Avanafil with doses ranging from 50 to 200 milligrams is the least effective, with only 20 to 30% more than the placebo in clinical trials.
  • Tadalafil has a different molecular structure to the Sildenafil and Verdanfil and is recommended by doctors even to take daily, and the significant side effect is muscle pain.
  • Studies confirm Vardenafil is ten times biochemically more potent than Sildenafil, and hence men need to take it in lower doses since higher doses may cause side effects.
  • Vardenafil is more potent because of its higher selectivity, which is the drug's ability to attach specific enzyme PDE5 to penal tissues.
  • Vardenafil has more selectivity than Sildenafil and Tadalafil to PDE5. Therefore, only low should be taken to avoid side effects.
  • Tadalafil is specific to PDE5 and PDE11 enzymes found in the heart, testicles, brain, and pituitary gland, but only a few researches on it.
  • Since Tadalafil has the most extended half-life, it is not essential to indulge in sexual activity soon after taking it and have it even after five to ten hours.
  • Avoiding nitrate medicines that lower the blood pressure long after taking Tadalafil is essential as it remains in the blood for a long time.
  • Sildenafil has a half-life of 4 hours, which is when the medication stays in the blood, whereas Tadalafil has a half-life of 17.5 hours, but the erection lasting power of both is the same.
  • Younger men can take Tadalafil more than Sildenafil for its long duration in the blood, and older men can opt for Sildenafil or Vardenafil.
  • Though taking Tadalafil has fewer side effects because staying in the blood for a long time may cause back pain for a few men.
  • A recent study confirms that Vardenafil improves erectile dysfunction in men with diabetes.
  • Sildenafil is better taken on an empty stomach to be more effective to have enough erection within an hour to last up to five hours and is ideal for older men with mild to moderate erectile dysfunction.
  • Vardenafil, similar to Sildenafil in structure and effect, also dissolves in the tongue for fast action but should avoid taking it with fatty foods as it takes more time to absorb in the blood.
  • Tadalafil is ideal for younger men and is best taken one or two hours before sex to last up to 36 hours and is recommended only in lower doses.
  • Avanafil acts within 30 minutes and can take it with or without food lasting up to six hours.

Knowing the many differences between oral ED medications, you need to choose the right online site to buy them for the best action, with no or limited side effects. Also, it is essential not to get fooled by the herbs and supplements without scientific evidence and buy the proper ED oral medication that suits you best at affordable costs from authentic online sites.