What is Flibanserin?

What is Flibanserin?
  • Posted On: Jun 14, 2021
  • By: Admin

Flibanserin is a medication sold with the brand name Addyi; it received approval for treating premenopausal women suffering from hypoactive sexual desire disorder. It would simply elevate your satisfying sexual events every month.

How Long Would Flibanserin Take to Perform its Action?

Flibanserin will start performing its positive effect, usually taking two to four weeks when the women will begin taking this drug. Also, make sure that the medicine is not used to increase sexual desire.

How to Consume the Flibanserin Tablet?

You need to consume this medicine via mouth as per the guidance of the doctor. Make sure you consume at bedtime as it will help to reduce the risk of fainting, low blood pressure, and drowsiness when you are awake. Always remember that after consuming the Flibanserin tablet, you do not consume alcohol till the next day. You can also read the instructions given on the table.

You must not eat grapefruit or avoid drinking grapefruit juice when consuming medicine unless or until your doctor will say to do so. This is because grapefruit will enhance the side effects while consuming this medicine.

You can consume this medicine regularly to derive its significant benefits. However, it would be best if you consumed it at the same time each day.

What are the Side Effects of the Flibanserin Tablets?

There are several side effects of the Flibanserin tablets are:

  • Dizziness
  • Tiredness
  • Nausea
  • Drowsiness

You might come across fainting and low blood pressure if you are consuming Flibanserin by yourself. However, if you are feeling lightheaded or dizzy, then you lie down right away.

You might face serious side effects and allergic reactions by consuming this medication. Therefore, before consuming the Flibanserin, you need to tell your pharmacists or doctor if you are allergic to its content, or you can confirm if you are suffering from any other allergic reaction.

At the time of pregnancy, you need to consume this medication when it is needed. Before undergoing surgery, you need to tell your doctor what products you are using, like nonprescription drugs, herbal products, and prescription drugs. You can consume the Flibanserin with or without the food but always make sure that you do not consume it in heavy meals. Else it would increase the risk of Cmax, AUC, and Tmax.

How Would the Drug Interaction Affect the Working of its Dosage?

The drug interaction would show how your medicine will perform its action on your body, and you will get to know about its side effects. The first drug got its approval to treat hypoactive sexual desire disorder by the FDA in 2015. Though primarily Boehringer Ingelheim developed this medication as the antidepressant medication at the time of clinical trials, it showed a lack of efficacy. Ingesting alcohol can lead to serious health issues, so it would be better for you not to consume it in any case. It would increase the hypotensive effects and lead to CNS depressants, and therefore it would eventually make the condition worse for you.

What is the Absorption Capacity of the Flibanserin Tablet?

It has an absolute oral availability of 33%, where it gets 98% bind with the protein in the serum.

Is it Possible to Buy Flibanserin Tablets Over the Counter?

It is a prescription drug that one can buy in the United States. You can even place your order online and get its doorstep delivery within a short period. All you have to do is to visit the online pharmacy store and place your order over there.

What is the mechanism of action of Flibanserin?

Flibanserin works as a full agonist in the raphe dorsal and frontal cortex. Though in the Hippocampus CA3 region, it only works as a partial agonist. Its mechanism follows the Kinsey dual sexual desire control model. Several sex steroids, neurotransmitters, and other hormones will eventually showcase their inhibitory or excitatory effects on your sexual response. It will simply modulate levels of dopamine and serotonin in the rat prefrontal cortex.

All your actions will be determined when the 5-HT1A receptor activation mediates them. It would also help in the enhancement of the neurotransmitter system by regulating the sexual response. Primarily this medication was developed as an antidepressant, and later on, it is used as the HSDD.

What to do if Someday Misses Consuming one of its Dosages?

If someone misses its dosage, they should make sure that he consumes its dosage the very next day and does not double its dosage. Else he would come across its severe side effects.

What is the route of elimination of Flibanserin?

A single 50mg of dosage will get eliminated from the body via urine (44%) and feces (51%).

What is the half-life of Flibanserin?

The half-life of the Flibanserin is 11 hours.

References:


https://www.everydayhealth.com/drugs/flibanserin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358680/
https://en.wikipedia.org/wiki/Hypoactive_sexual_desire_disorder
https://www.rxlist.com/consumer_flibanserin_addyi/drugs-condition.htm